Treatment guide · Wilmslow

Polynucleotides

Learn about Polynucleotides at Dr Sknn, including suitability, treatment planning, the procedure, recovery, material risks, aftercare and frequently asked questions. Your clinician will confirm whether this treatment—or another treatment—is appropriate for you.

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Polynucleotides before and after result at Dr Sknn
Treatment planning

What treatment planning should establish.

These four points support treatment planning. The detailed guide below covers this treatment.

Dr Eddie Shaffu, Medical Lead at Dr Sknn
Dr Eddie Shaffu Medical Lead · Dr Sknn
The treatment explained

About Polynucleotides.

Read more about Polynucleotides Treatment details and clinical context

Polynucleotides in Skin Rejuvenation | Dr Sknn Aesthetic Skin Clinic, UK

Strengthening of micro-blood vessels, promoting better blood flow and nutrient delivery

Regulation of melanocyte function, reducing pigmentation and evening out skin tone

A consultation may conclude that a different treatment—or no treatment—is the safest and most appropriate recommendation.
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What to expect

Before, during and after your treatment.

Your exact experience and recovery are individual. Your clinician will explain what applies to you.

01 · Before Who is Unsuitable for Polynucleotide Treatments?

Polynucleotide treatments may not be suitable for individuals with certain medical conditions, allergies, or skin infections in the treatment area. A thorough consultation with a qualified clinician at Dr Sknn Aesthetic Skin Clinic will help determine if this treatment is right for you.

02 · During Are Polynucleotide Treatments Painful?

Polynucleotide treatments are generally well-tolerated by patients. A topical numbing cream can be applied before the procedure to minimize any discomfort. Some patients may experience mild sensations during the injection process, but these are typically brief and manageable.

03 · After Recovery, review and aftercare.

You receive individual aftercare, warning signs and review guidance. Response and recovery vary between patients, and no particular outcome can be guaranteed.

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Photographs show individual patients. Results vary and do not guarantee a particular outcome.

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Patient reviews

What patients say about Dr Sknn.

Recent public Google feedback and verified Pabau appointment reviews. Reviews describe individual experiences and do not guarantee a particular treatment outcome.

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Areas and concerns

Areas Treated with Polynucleotide Therapy

Review the treatment areas and concerns below. Your clinician will confirm suitability, preparation, recovery and aftercare before treatment.

View treatment areas and concerns 12 options covered on this page
Face Treatment with PolynucleotidesThe face is one of the most common areas treated with polynucleotide therapy. As we age, the skin on our face loses elasticity and volume, leading to the appearance of fine lines, wrinkles, and sagging. Polynucleotide treatments can help to:
Under Eyes and EyelidsTreatment with PolynucleotidesThe delicate skin under the eyes and on the eyelids is particularly susceptible to aging, leading to dark circles, puffiness, and sagging. Polynucleotide treatments can specifically target these areas to:
Neck Treatment with PolynucleotidesThe décolletage, or the upper chest area, is another area where polynucleotide treatments can be highly effective. This delicate area is prone to sun damage and aging, resulting in wrinkles, sunspots, and a loss of skin elasticity. Polynucleotide therapy can:
Décolletage Treatment with PolynucleotidesThe décolletage, or the upper chest area, is another area where polynucleotide treatments can be highly effective. This delicate area is prone to sun damage and aging, resulting in wrinkles, sunspots, and a loss of skin elasticity. Polynucleotide therapy can:
Abdominal Treatment with PolynucleotidesThe abdomen is another area that can benefit from polynucleotide treatments, especially for individuals who have experienced significant weight loss, pregnancy, or stretch marks. The treatment can:
Thigh/Leg Treatment with PolynucleotidesThe thighs are a common area of concern, particularly when it comes to cellulite, skin laxity, and stretch marks. Polynucleotide treatments can:
Buttocks Treatment with PolynucleotidesFor those seeking a smoother, more toned appearance in the buttocks, polynucleotide treatments offer several benefits:
Hand Treatment with PolynucleotidesThe hands are often one of the first places to show signs of aging due to constant exposure to the elements. Polynucleotide treatments can:
Scalp and Hair Treatment with PolynucleotidesPolynucleotide treatments can also be applied to the scalp to address hair loss and promote healthier hair growth. The treatment works by:
Eyelash Growth Treatment with PolynucleotidesPolynucleotide treatments offer a cutting-edge solution for individuals seeking to enhance their natural eyelashes, providing a non-invasive method to strengthen, lengthen, and volumize lashes. The treatment can: Strengthen and Thicken Lashes: Polynucleotide therapy helps to fortify the lashes, making them stronger and reducing breakage. This results in fuller, more resilient eyelashes. Stimulate Natural Growth: By stimulating the hair follicles, polynucleotides promote the natural growth of longer, thicker lashes, enhancing their overall appearance. Improve Lash Health: The treatment nourishes the lash line, improving the overall health and vitality of your lashes, making them look and feel healthier and more vibrant.
What to Expect Before the ProcedureAt Dr Sknn Aesthetic Skin Clinic, we offer a free, doctor-led consultation before any polynucleotide treatment. During this consultation, a full medical history will be taken, and a detailed assessment of your skin's condition will be conducted. The clinician will explain the procedure, potential risks, and expected outcomes. Each treatment plan is customised to address your specific skin concerns and achieve the best possible results.
What to Expect After the ProcedureYou can return to your normal activities immediately after the procedure, although you may experience some redness, swelling, or bruising, which should subside within a few days. The microneedling or nanoneedling process may cause slight redness or sensitivity, but these effects are temporary and typically resolve within a few days.
Questions before booking

Frequently asked questions.

Preparation, treatment, recovery, suitability and aftercare guidance to support your consultation.

How Do Polynucleotides Work?
Polynucleotides work by stimulating cell proliferation and regeneration. When applied to the skin using techniques such as microneedling, nanoneedling, microboluses with a fine needle, or using a cannula, they activate receptors on skin cells, leading to: Increased production of collagen and elastin Improved hydration through enhanced hyaluronic acid production
Can Polynucleotide Treatments Be Reversed?
Polynucleotide treatments are designed to work with your body’s natural repair processes and are not typically reversible. However, since the treatments are non-invasive and use natural DNA fragments, any effects will gradually diminish over time if maintenance treatments are not continued.
Are Polynucleotide Treatments Safe?
Yes, polynucleotide treatments are considered safe when administered by a trained and qualified professional. The polynucleotides used are highly purified and closely resemble human DNA, reducing the risk of adverse reactions. The treatment has been supported by scientific research and is widely used in both aesthetic and regenerative medicine.
Are Polynucleotide Treatments Painful?
Polynucleotide treatments are generally well-tolerated by patients. A topical numbing cream can be applied before the procedure to minimize any discomfort. Some patients may experience mild sensations during the injection process, but these are typically brief and manageable.
What Type of Polynucleotide is Used in the Treatment?
The polynucleotides used in these treatments are highly purified fragments of DNA derived from sources such as salmon or trout sperm, which closely resemble human DNA. These fragments are carefully processed and sterilised to ensure safety and effectiveness.
Do Polynucleotide Treatments Have Any Side Effects?
As with any injectable treatment, there may be minor side effects such as redness, swelling, or bruising at the injection site. These effects are usually temporary and resolve within a few days. Your clinician will provide aftercare instructions to minimise any discomfort and promote healing.
How Long Do Polynucleotide Treatment Results Last?
The results of polynucleotide treatments can vary depending on the individual and the area treated. Generally, patients can expect the effects to last for several months, with gradual improvement seen over time. For long-lasting results, maintenance treatments every 6 to 12 months are recommended.
Who is Unsuitable for Polynucleotide Treatments?
Polynucleotide treatments may not be suitable for individuals with certain medical conditions, allergies, or skin infections in the treatment area. A thorough consultation with a qualified clinician at Dr Sknn Aesthetic Skin Clinic will help determine if this treatment is right for you.
Am I Suitable for Polynucleotide Treatments?
Most individuals looking to improve skin texture, reduce signs of aging, or address specific skin concerns such as scarring or pigmentation are suitable candidates for polynucleotide treatments. Your clinician will assess your skin and medical history to ensure the treatment aligns with your goals.
Where Can Polynucleotide Treatments Be Used?
Polynucleotide treatments can be applied to various areas of the face and body, including the body, face, under eyes, neck, décolletage, hands, legs, and scalp. The treatment is versatile and can be tailored to target specific concerns such as fine lines, wrinkles, scarring, or hair loss.
Can Polynucleotide Treatments Be Combined With Other Procedures?
Yes, polynucleotide treatments can be combined with other aesthetic procedures, such as anti-wrinkle injections or dermal fillers, to enhance overall results. Your clinician will discuss the best combination of treatments to achieve your desired outcome.
What Results Will I See With Polynucleotide Treatments?
Patients typically notice improvements in skin texture, hydration, and elasticity within a few weeks of treatment. Over time, you may also see a reduction in fine lines, wrinkles, skin quality and pigmentation. When used for hair loss, new hair growth and improved hair quality may also be observed. Results will vary based on individual factors, including skin condition and lifestyle.
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